HIV‐1 neutralizing antibodies: understanding nature's pathways

JR Mascola, BF Haynes - Immunological reviews, 2013 - Wiley Online Library
The development of an effective vaccine has been hindered by the enormous diversity of
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …

Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

R Schreck, P Rieber, PA Baeuerle - The EMBO journal, 1991 - embopress.org
Hydrogen peroxide and oxygen radicals are agents commonly produced during
inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can …

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

DD Richman, T Wrin, SJ Little… - Proceedings of the …, 2003 - National Acad Sciences
A recombinant virus assay was used to characterize in detail neutralizing antibody
responses directed at circulating autologous HIV in plasma. Examining serial plasma …

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

M Thali, JP Moore, C Furman, M Charles… - Journal of …, 1993 - Am Soc Microbiol
Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …

Designing CD4 immunoadhesins for AIDS therapy

DJ Capon, SM Chamow, J Mordenti, SA Marsters… - Nature, 1989 - nature.com
A newly-constructed antibody-like molecule containing the gp! 20-binding domain of the
receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes …

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

NT Freund, H Wang, L Scharf, L Nogueira… - Science translational …, 2017 - science.org
Some HIV-1–infected patients develop broad and potent HIV-1 neutralizing antibodies
(bNAbs) that when passively transferred to mice or macaques can treat or prevent infection …

Immunopathogenesis of HIV infection

G Pantaleo, AS Fauci - Annual review of microbiology, 1996 - annualreviews.org
The rate of progression of HIV disease may be substantially different among HIV-infected
individuals. Following infection of the host with any virus, the delicate balance between virus …

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells

MW Makgoba, ME Sanders, GEG Luce, ML Dustint… - Nature, 1988 - nature.com
Cell-cell adhesion is essential for many immunological functions1–4. The LFA-1 molecule, a
member of a superfamily of adhesion molecules, participates in adhesion which is critical to …

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

LA Lasky, G Nakamura, DH Smith, C Fennie… - Cell, 1987 - cell.com
The primary event in the infection of cells by HIV is the interaction between the viral
envelope glycoprotein, gp120, and its cellular receptor, CD4. A recombinant form of gp120 …