Societal Impact Statement Plants and fungi have provided, or inspired, key pharmaceuticals
for global health challenges, including cancer, heart disease, dementia, and malaria, and …

Plants produce more than 20,000 nitrogen-containing heterocyclic metabolites called
alkaloids. These chemicals serve numerous eco-physiological functions in the plants as well …

Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with
marketed pharmaceutical activities against a wide range of indications, including cancer …

Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …

Hyperforin is the compound responsible for the effectiveness of St. John's wort (Hypericum
perforatum) as an antidepressant, but its complete biosynthetic pathway remains unknown …

Indole‐containing compounds demonstrate an array of biological activities relevant to
numerous human diseases. The biological activities of diverse indole‐based agents are …

While plants are an abundant source of valuable natural products, it is often challenging to
produce those products for commercial application. Often organic synthesis is too expensive …

Monoterpenoid indole alkaloids (MIAs) are a large group of biosynthetic compounds, which
have pharmacological properties. One of these MIAs, reserpine, was discovered in the …

Major hurdles in plant biosynthetic pathway elucidation and engineering include the need
for rapid testing of enzyme candidates and the lack of complex substrates that are often not …

Semi-synthetic derivatives of camptothecin, a quinoline alkaloid found in the Camptotheca
acuminata tree, are potent anticancer agents. Here we discovered two C. acuminata …