To date, there has been little investigation of the neurobiological basis of emotion
processing abnormalities in psychiatric populations. We have previously discussed two …

OBJECTIVE: Voxel-based morphometry is a method for detecting group differences in the
density or volume of brain matter. The authors reviewed the literature on use of voxel-based …

Considerable uncertainty exists about the defining brain changes associated with bipolar
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …

The hippocampus plays key roles in cognition and affect and serves as a model system for
structure/function studies in animals. So far, its complex anatomy has challenged …

Recently, functional network connectivity (FNC, defined as the temporal correlation among
spatially distant brain networks) has been used to examine the functional organization of …

OBJECTIVE: A number of studies have used magnetic resonance imaging to examine
volumetric differences in temporal structures in subjects suffering from major depressive …

Background Psychotic disorders, such as schizophrenia, are associated with
neuroanatomical abnormalities, but whether these predate the onset of symptoms or …

Background: Youths with bipolar disorder are ideal for studying illness pathophysiology
given their early presentation, lack of extended treatment, and high genetic loading. Adult …

BACKGROUND: Schizophrenia and bipolar disorder are severe psychiatric diseases with
overlapping symptomatology. Widespread brain morphologic abnormalities, including …

The authors review existing structural and functional neuroimaging studies of patients with
bipolar disorder and discuss how these investigations enhance our understanding of the …