Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …
[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy
CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …
Overview on molecular biomarkers for laryngeal cancer: looking for new answers to an old problem
Simple Summary Laryngeal cancer represents one of the most common head and neck
cancers worldwide. It can arise in different larynx subsites, each associated with specific …
cancers worldwide. It can arise in different larynx subsites, each associated with specific …
Effect of long-term human exposure to environmental heavy metals on the expression of detoxification and DNA repair genes
The present study was designed to evaluate the influence of long-term environmental
human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the …
human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the …
Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks
D Kidane - International journal of molecular sciences, 2018 - mdpi.com
Infections contribute to carcinogenesis through inflammation-related mechanisms. H. pylori
infection is a significant risk factor for gastric carcinogenesis. However, the molecular …
infection is a significant risk factor for gastric carcinogenesis. However, the molecular …
Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
Although a plethora of studies have examined tobacco smoke-cancer disease association,
the involvement of cellular genetic toxicity remains unclear. Therefore, the present study …
the involvement of cellular genetic toxicity remains unclear. Therefore, the present study …
Molecular pathways and druggable targets in head and neck squamous cell carcinoma
F Kordbacheh, CS Farah - Cancers, 2021 - mdpi.com
Simple Summary Head and neck cancer remains a significant burden on patients and global
health systems. Traditional approaches to therapy have included surgery, and more recently …
health systems. Traditional approaches to therapy have included surgery, and more recently …
Lead induces DNA damage and alteration of ALAD and antioxidant genes mRNA expression in construction site workers
Oxidative stress and DNA damage are considered as possible mechanisms involved in lead
toxicity. To test this hypothesis, DNA damage and expression variations of aminolevulinic …
toxicity. To test this hypothesis, DNA damage and expression variations of aminolevulinic …
Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma
Defects in the DNA damage repair pathway contribute to cancer. The major pathway for
oxidative DNA damage repair is base excision repair (BER). Although BER pathway genes …
oxidative DNA damage repair is base excision repair (BER). Although BER pathway genes …
Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice
Maintaining germline genome integrity is essential and enormously complex. Although
many proteins are involved in DNA replication, proofreading, and repair, mutator alleles …
many proteins are involved in DNA replication, proofreading, and repair, mutator alleles …