Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy

CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

Overview on molecular biomarkers for laryngeal cancer: looking for new answers to an old problem

M Falco, C Tammaro, T Takeuchi, AM Cossu… - Cancers, 2022 - mdpi.com
Simple Summary Laryngeal cancer represents one of the most common head and neck
cancers worldwide. It can arise in different larynx subsites, each associated with specific …

Effect of long-term human exposure to environmental heavy metals on the expression of detoxification and DNA repair genes

SA Al Bakheet, IM Attafi, ZH Maayah, AR Abd-Allah… - Environmental …, 2013 - Elsevier
The present study was designed to evaluate the influence of long-term environmental
human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the …

Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks

D Kidane - International journal of molecular sciences, 2018 - mdpi.com
Infections contribute to carcinogenesis through inflammation-related mechanisms. H. pylori
infection is a significant risk factor for gastric carcinogenesis. However, the molecular …

Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects

AM Alsaad, MN Al-Arifi, ZH Maayah… - Toxicology …, 2019 - Taylor & Francis
Although a plethora of studies have examined tobacco smoke-cancer disease association,
the involvement of cellular genetic toxicity remains unclear. Therefore, the present study …

Molecular pathways and druggable targets in head and neck squamous cell carcinoma

F Kordbacheh, CS Farah - Cancers, 2021 - mdpi.com
Simple Summary Head and neck cancer remains a significant burden on patients and global
health systems. Traditional approaches to therapy have included surgery, and more recently …

Lead induces DNA damage and alteration of ALAD and antioxidant genes mRNA expression in construction site workers

Z Akram, S Riaz, MA Kayani, S Jahan… - … of environmental & …, 2019 - Taylor & Francis
Oxidative stress and DNA damage are considered as possible mechanisms involved in lead
toxicity. To test this hypothesis, DNA damage and expression variations of aminolevulinic …

Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma

I Mahjabeen, K Ali, X Zhou, MA Kayani - Tumor Biology, 2014 - Springer
Defects in the DNA damage repair pathway contribute to cancer. The major pathway for
oxidative DNA damage repair is base excision repair (BER). Although BER pathway genes …

Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice

TA Sasani, AR Quinlan, K Harris - Elife, 2024 - elifesciences.org
Maintaining germline genome integrity is essential and enormously complex. Although
many proteins are involved in DNA replication, proofreading, and repair, mutator alleles …