N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

The gut-brain axis (GBA) consists of bidirectional communication between the central and
the enteric nervous system, linking emotional and cognitive centers of the brain with …

Exercise promotes learning and memory formation. These effects depend on increases in
hippocampal BDNF, a growth factor associated with cognitive improvement and the …

The link between gut microbiome and brain is being slowly acknowledged due to the
speculated role of resident gut microbial community in altering the functions of gut-brain axis …

Several lines of evidence suggest that brain function and behaviour are influenced by
microbial metabolites. Key products of the microbiota are short-chain fatty acids (SCFAs) …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and
gene regulation, but the precise mechanisms of this process are largely unknown. Here we …

A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

In the last decade, emerging evidence has reported correlations between the gut
microbiome and human health and disease, including those affecting the brain. We …

Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …