Toward a fully resolved fungal tree of life

TY James, JE Stajich, CT Hittinger… - Annual Review of …, 2020 - annualreviews.org
In this review, we discuss the current status and future challenges for fully elucidating the
fungal tree of life. In the last 15 years, advances in genomic technologies have …

Combatting the evolution of antifungal resistance in Cryptococcus neoformans

A Bermas, J Geddes‐McAlister - Molecular microbiology, 2020 - Wiley Online Library
Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

Fungal species concepts in the genomics era

J Xu - Genome, 2020 - cdnsciencepub.com
The 140 000 or so fungal species reported so far are heterogeneously defined based on
varying criteria such as morphological, physiological, mating, and (or) molecular features …

Assessing global fungal threats to humans

J Xu - mLife, 2022 - Wiley Online Library
Fungi are an integral part of the earth's biosphere. They are broadly distributed in all
continents and ecosystems and play a diversity of roles. Here, I review our current …

[HTML][HTML] Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans

V Mixão, T Gabaldón - BMC biology, 2020 - Springer
Background Opportunistic yeast pathogens of the genus Candida are an important medical
problem. Candida albicans, the most prevalent Candida species, is a natural commensal of …

Clonality, inbreeding, and hybridization in two extremotolerant black yeasts

C Gostinčar, X Sun, A Černoša, C Fang… - …, 2022 - academic.oup.com
Background The great diversity of lifestyles and survival strategies observed in fungi is
reflected in the many ways in which they reproduce and recombine. Although a complete …

A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes …

S de Hoog, TJ Walsh, SA Ahmed… - Journal of clinical …, 2023 - Am Soc Microbiol
The rapid pace of name changes of medically important fungi is creating challenges for
clinical laboratories and clinicians involved in patient care. We describe two sources of …

Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification

GM Matos, MD Lewis, C Talavera-López, M Yeo… - Elife, 2022 - elifesciences.org
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic
exchange. However, the presence and epidemiological relevance of genetic exchange in …

[HTML][HTML] Global Analyses of Multi-Locus Sequence Typing Data Reveal Geographic Differentiation, Hybridization, and Recombination in the Cryptococcus gattii …

M Hitchcock, J Xu - Journal of Fungi, 2023 - mdpi.com
Cryptococcus gattii species complex (CGSC) is a basidiomycete haploid yeast and globally
distributed mammalian pathogen. CGSC is comprised of six distinct lineages (VGI, VGII …

Roles for structural biology in the discovery of drugs and agrochemicals targeting sterol 14α-demethylases

BC Monk, MV Keniya - Journal of Fungi, 2021 - mdpi.com
Antifungal drugs and antifungal agrochemicals have significant limitations. These include
several unintended consequences of their use including the growing importance of intrinsic …