Testing at scale during the COVID-19 pandemic

TR Mercer, M Salit - Nature Reviews Genetics, 2021 - nature.com
Assembly and publication of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) genome in January 2020 enabled the immediate development of tests to detect the …

CRISPR-based tools: Alternative methods for the diagnosis of COVID-19

F Palaz, AK Kalkan, A Tozluyurt, M Ozsoz - Clinical biochemistry, 2021 - Elsevier
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
spread all over the world rapidly and caused a global pandemic. To prevent the virus from …

The COUGHVID crowdsourcing dataset, a corpus for the study of large-scale cough analysis algorithms

L Orlandic, T Teijeiro, D Atienza - Scientific Data, 2021 - nature.com
Cough audio signal classification has been successfully used to diagnose a variety of
respiratory conditions, and there has been significant interest in leveraging Machine …

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

D Butler, C Mozsary, C Meydan, J Foox… - Nature …, 2021 - nature.com
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) killed over a million people, including> 25,000 in New York City (NYC) alone. The …

Unlocking capacities of genomics for the COVID-19 response and future pandemics

S Knyazev, K Chhugani, V Sarwal, R Ayyala, H Singh… - Nature …, 2022 - nature.com
During the COVID-19 pandemic, genomics and bioinformatics have emerged as essential
public health tools. The genomic data acquired using these methods have supported the …

[HTML][HTML] Monkeypox: another test for PCR

JF Huggett, D French, DM O'Sullivan… - …, 2022 - eurosurveillance.org
Monkeypox was declared a public health emergency of international concern by the World
Health Organization (WHO) on 23 July 2022. Between 1 January and 23 July 2022, 16,016 …

Designing sensitive viral diagnostics with machine learning

HC Metsky, NL Welch, PP Pillai, NJ Haradhvala… - Nature …, 2022 - nature.com
Abstract Design of nucleic acid-based viral diagnostics typically follows heuristic rules and,
to contend with viral variation, focuses on a genome's conserved regions. A design process …

The need for more and better testing for COVID-19

YC Manabe, JS Sharfstein, K Armstrong - Jama, 2020 - jamanetwork.com
With continued community transmission of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in the US, there has been sustained focus on the role of …

SARS-CoV-2 detection with aptamer-functionalized gold nanoparticles

S Aithal, S Mishriki, R Gupta, RP Sahu, G Botos… - Talanta, 2022 - Elsevier
A rapid detection test for SARS-CoV-2 is urgently required to monitor virus spread and
containment. Here, we describe a test that uses nanoprobes, which are gold nanoparticles …

Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out

RRG Soares, AS Akhtar, IF Pinto, N Lapins, D Barrett… - Lab on a Chip, 2021 - pubs.rsc.org
With its origin estimated around December 2019 in Wuhan, China, the ongoing SARS-CoV-
2 pandemic is a major global health challenge. The demand for scalable, rapid and …