The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

Paracrine Wnt/β-catenin signalling is important during developmental processes, tissue
regeneration and stem cell regulation. Wnt proteins are morphogens, which form …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Wnt signaling is one of the key signaling pathways that govern numerous physiological
activities such as growth, differentiation and migration during development and …

Wnt proteins are secreted glycoproteins that regulate multiple processes crucial to the
development and tissue homeostasis of multicellular organisms, including tissue patterning …

Extracellular signals are often transduced by dynamic signaling complexes ("
signalosomes") assembled by oligomerizing hub proteins following their recruitment to …

Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that
regulate the exchange of signaling molecules and their receptors within tissues. However …

Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …