Macrophage polarization and plasticity in systemic lupus erythematosus

MM Ahamada, Y Jia, X Wu - Frontiers in immunology, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every
organ. The condition mostly happens to adults but is also found in children, and the latter …

Statin-regulated phagocytosis and efferocytosis in physiological and pathological conditions

A Tajbakhsh, SM Gheibihayat, H Askari… - Pharmacology & …, 2022 - Elsevier
Efferocytosis (clearance of apoptotic cells by phagocytosis without inducing inflammation
and autoimmunity) is an important mechanism in the resolution of inflammatory processes …

Apoptotic neurons and amyloid-beta clearance by phagocytosis in Alzheimer's disease: Pathological mechanisms and therapeutic outlooks

A Tajbakhsh, M Read, GE Barreto… - European Journal of …, 2021 - Elsevier
Neuronal survival and axonal renewal following central nervous system damage and in
neurodegenerative illnesses, such as Alzheimer's disease (AD), can be enhanced by fast …

[HTML][HTML] The complex roles of efferocytosis in cancer development, metastasis, and treatment

A Tajbakhsh, A Movahedpour, A Savardashtaki… - Biomedicine & …, 2021 - Elsevier
When tumor cells are killed by targeted therapy, radiotherapy, or chemotherapy, they trigger
their primary tumor by releasing pro-inflammatory cytokines. Microenvironmental …

Use of DAMPs and SAMPs as therapeutic targets or therapeutics: a note of caution

WG Land - Molecular Diagnosis & Therapy, 2020 - Springer
This opinion article discusses the increasing attention paid to the role of activating damage-
associated molecular patterns (DAMPs) in initiation of inflammatory diseases and …

Alarmins and c-Jun N-Terminal Kinase (JNK) signaling in neuroinflammation

ND Anfinogenova, MT Quinn, IA Schepetkin… - Cells, 2020 - mdpi.com
Neuroinflammation is involved in the progression or secondary injury of multiple brain
conditions, including stroke and neurodegenerative diseases. Alarmins, also known as …

Efferocytosis in multisystem diseases

Y Zhang, Y Wang, J Ding, P Liu - Molecular medicine …, 2022 - spandidos-publications.com
Efferocytosis, the phagocytosis of apoptotic cells performed by both specialized phagocytes
(such as macrophages) and non‑specialized phagocytes (such as epithelial cells), is …

Macrophage efferocytosis in cardiac pathophysiology and repair

Y Li, Q Li, GC Fan - Shock, 2021 - journals.lww.com
As an integral component of cardiac tissue, macrophages are critical for cardiac
development, adult heart homeostasis, as well as cardiac healing. One fundamental function …

The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and treatment …

A Tajbakhsh, SM Gheibihayat, N Karami… - Obesity …, 2022 - Wiley Online Library
Obesity is associated with changes in the resolution of acute inflammation that contribute to
the clinical complications. The exact mechanisms underlying unresolved inflammation in …

The effect of cigarette smoke exposure on efferocytosis in chronic obstructive pulmonary disease; molecular mechanisms and treatment opportunities

A Tajbakhsh, SM Gheibihayat, D Mortazavi… - COPD: Journal of …, 2021 - Taylor & Francis
Cigarette smoking-related inflammation, cellular stresses, and tissue destruction play a key
role in lung disease, such as chronic obstructive pulmonary disease (COPD). Notably …