Integrating plant molecular farming and materials research for next-generation vaccines

YH Chung, D Church, EC Koellhoffer, E Osota… - Nature Reviews …, 2022 - nature.com
Biologics—medications derived from a biological source—are increasingly used as
pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial …

Stimuli-responsive In situ gelling system for nose-to-brain drug delivery

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …

Progress in brain targeting drug delivery system by nasal route

AR Khan, M Liu, MW Khan, G Zhai - Journal of Controlled Release, 2017 - Elsevier
The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

Chitosan-based drug delivery systems

A Bernkop-Schnürch, S Dünnhaupt - European journal of pharmaceutics …, 2012 - Elsevier
Within the past 20years, a considerable amount of work has been published on chitosan
and its potential use in drug delivery systems. In contrast to all other polysaccharides having …

Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review

PG Djupesland - Drug delivery and translational research, 2013 - Springer
Nasal delivery is the logical choice for topical treatment of local diseases in the nose and
paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also …

Biodegradation, biodistribution and toxicity of chitosan

T Kean, M Thanou - Advanced drug delivery reviews, 2010 - Elsevier
Chitosan is a natural polysaccharide that has attracted significant scientific interest during
the last two decades. It is a potentially biologically compatible material that is chemically …

Chitosan chemistry and pharmaceutical perspectives

MNVR Kumar, RAA Muzzarelli, C Muzzarelli… - Chemical …, 2004 - ACS Publications
In the chitin bibliography, a major reference is the book written by Richards in 1951
“primarily for entomologists and other invertebrate zoologists” but also, in the author's hope …

Chitosan nanoparticles: a promising system in novel drug delivery

K Nagpal, SK Singh, DN Mishra - Chemical and Pharmaceutical …, 2010 - jstage.jst.go.jp
The ability of nanoparticles to manipulate the molecules and their structures has
revolutionized the conventional drug delivery system. The chitosan nanoparticles, because …

Chitosan microspheres as a potential carrier for drugs

VR Sinha, AK Singla, S Wadhawan, R Kaushik… - International journal of …, 2004 - Elsevier
Chitosan is a biodegradable natural polymer with great potential for pharmaceutical
applications due to its biocompatibility, high charge density, non-toxicity and mucoadhesion …

Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants

X Li, R Xing, C Xu, S Liu, Y Qin, K Li, H Yu, P Li - Carbohydrate polymers, 2021 - Elsevier
Vaccines have always been the most effective preventive treatment. Advancements in the
field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines …