Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …

Abstract Structure-based virtual screening is a key tool in early drug discovery, with growing
interest in the screening of multi-billion chemical compound libraries. However, the success …

Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and
propagating action potentials. Consistent with their physiological significance, dysfunction …

Mentha arvensis is an herbaceous plant commonly known as peppermint or Japanese mint.
This study investigated the toxic potential and repellent efficacy of M. arvensis essential oil …

Abstract Voltage-activated Na+(Na V) channels are crucial contributors to rapid electrical
signaling in the human body. As such, they are among the most targeted membrane proteins …

Voltage-gated ion channels (VGICs) are pivotal in regulating electrical activity in excitable
cells and are critical pharmaceutical targets for treating many diseases including cardiac …

KCNQ (Kv7) channels are voltage-gated, phosphatidylinositol 4, 5-bisphosphate-(PIP 2-)
modulated potassium channels that play essential roles in regulating the activity of neurons …

Introduction Automated patch clamp (APC) is now well established as a mature technology
for ion channel drug discovery in academia, biotech and pharma companies, and in contract …

Voltage-gated sodium channel α-subunits (NaV1. 1–1.9) initiate and propagate action
potentials in neurons and myocytes. The NaV β-subunits (β1–4) have been shown to …

Ion channels play a crucial role in a variety of physiological and pathological processes,
making them attractive targets for drug development in diseases such as diabetes, epilepsy …