Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Molecular targeted therapies are revolutionized therapeutics which interfere with specific
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

A major metabolic aberration associated with cancer is a change in glucose metabolism.
Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the …

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and
ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There …

Background Naïve lymphocytes circulate in the body in a resting state, but upon recognition
of foreign antigen and receipt of proper costimulatory signals, these cells become activated …