Environmental influences on the pace of brain development
Childhood socio-economic status (SES), a measure of the availability of material and social
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
Protective genes and pathways in Alzheimer's disease: moving towards precision interventions
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
Early-initiated childhood reading for pleasure: associations with better cognitive performance, mental well-being and brain structure in young adolescence
BackgroundChildhood is a crucial neurodevelopmental period. We investigated whether
childhood reading for pleasure (RfP) was related to young adolescent assessments of …
childhood reading for pleasure (RfP) was related to young adolescent assessments of …
Influence of cognitive reserve on cognitive trajectories: role of brain pathologies
X Li, R Song, X Qi, H Xu, W Yang, M Kivipelto… - Neurology, 2021 - AAN Enterprises
Background and Objectives Evidence on the association of cognitive reserve (CR) with the
cognitive trajectories is limited. We aimed to examine the influence of CR indicator on …
cognitive trajectories is limited. We aimed to examine the influence of CR indicator on …
The mediating role of allostatic load in the relationship between early life adversity and cognitive function across the adult lifespan
Early life adversity is consequential for poor cognitive health in mid to late-life. Early life
adversity is associated with higher allostatic load, a biological indicator of physiological …
adversity is associated with higher allostatic load, a biological indicator of physiological …
Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …
models, directed at understanding and modifying the relationship between cognition and …
Calpain inhibitors as potential therapeutic modulators in neurodegenerative diseases
It is considered a significant challenge to understand the neuronal cell death mechanisms
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …
Personality associations with amyloid and tau: Results from the Baltimore Longitudinal Study of Aging and meta-analysis
Background Higher neuroticism and lower conscientiousness are risk factors for Alzheimer's
disease and related dementias, but the underlying neuropathological correlates remain …
disease and related dementias, but the underlying neuropathological correlates remain …
Noradrenaline in the aging brain: promoting cognitive reserve or accelerating Alzheimer's disease?
M Mather - Seminars in cell & developmental biology, 2021 - Elsevier
Many believe that engaging in novel and mentally challenging activities promotes brain
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …