The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

Nasal delivery offers many benefits over other conventional routes of delivery (eg oral or
intravenous administration). Benefits include, among others, a fast onset of action, non …

In vitro–in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally
inhaled drug based on in vitro drug measurements. In vitro measurements include physical …

This review aims to cement three hot topics in drug delivery:(a) the pre-formulation of new
products intended for nose-to-brain delivery;(b) the development of nasal casts for studying …

The nasal route has been investigated as a promising alternative for drug delivery to the
central nervous system, avoiding passage through the blood–brain barrier and improving …

Introduction This work aimed to develop chitosan-coated cubosomal nanoparticles intended
for nose-to-brain delivery of paliperidone palmitate. They were compared with standard and …

The aim of this study was to develop an innovative in situ gelling suspension for effective
nasal delivery of fluticasone. Pectin, gellan gum and sodium hyaluronate were used as …

In this work we present the development of in situ gelling nanosuspension as advanced form
for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling …

Nose-to-brain delivery is a promising way to improve the treatment of central nervous system
disorders, as it allows the bypassing of the blood–brain barrier. However, it is still largely …

Donepezil nasal delivery strategies are being continuously investigated for advancing
therapy in Alzheimer's disease. The aim of this study was to develop a chitosan-based …