Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications

A Gowen, F Shahjin, S Chand, KE Odegaard… - Frontiers in cell and …, 2020 - frontiersin.org
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …

[HTML][HTML] Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

S Liu, M Fan, JX Xu, LJ Yang, CC Qi, QR Xia… - Journal of …, 2022 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by a
progressive decline in cognitive ability. Exosomes derived from bone-marrow mesenchymal …

[HTML][HTML] Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Y Fan, Z Chen, M Zhang - Journal of Translational Medicine, 2022 - Springer
Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease
(AD), and Parkinson's disease (PD), affect millions of people around the world. Great efforts …

[HTML][HTML] Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

[HTML][HTML] The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review

P Hong, H Yang, Y Wu, K Li, Z Tang - Stem cell research & therapy, 2019 - Springer
Exosomes are extracellular membranous nanovesicles that mediate local and systemic
intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into …

Adipose‐Derived stem cells: current applications and future directions in the regeneration of multiple tissues

J Zhang, Y Liu, Y Chen, L Yuan, H Liu… - Stem Cells …, 2020 - Wiley Online Library
Adipose‐derived stem cells (ADSCs) can maintain self‐renewal and enhanced
multidifferentiation potential through the release of a variety of paracrine factors and …

Diagnostic and therapeutic potential of exosomes in Alzheimer's disease

T Soares Martins, D Trindade, M Vaz… - Journal of …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles released by almost all cell types in physiological
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …

[HTML][HTML] Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …

[HTML][HTML] Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer's disease

M Guo, Z Yin, F Chen, P Lei - Alzheimer's Research & Therapy, 2020 - Springer
Alzheimer's disease (AD) has been a devastating public health with the development of
global aging. Approaches for reducing the current AD epidemic are becoming a primary …