An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

U Hossain, AK Das, S Ghosh, PC Sil - Food and chemical toxicology, 2020 - Elsevier
Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have
been proven to be the most efficient remedy for controlling postprandial hyperglycemia and …

Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application

AML Seca, DCGA Pinto - International journal of molecular sciences, 2018 - mdpi.com
Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

[HTML][HTML] Betulinic acid in the treatment of tumour diseases: Application and research progress

W Jiang, X Li, S Dong, W Zhou - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation,
chemical synthesis and biotransformation from birch. BA has antitumour activity, and its …

Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery

F Majolo, LKOB Delwing, DJ Marmitt… - Phytochemistry …, 2019 - Elsevier
Cancer is one of the largest causes of morbimortality in the world and due to its prevalence
the discovery of novel anticancer drugs in of great importance. The past century brought …

New pharmacological opportunities for betulinic acid

JL Ríos, S Máñez - Planta medica, 2018 - thieme-connect.com
Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated
from birch trees, but present in many other botanical sources. It is found in different plant …

Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance

T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …

A comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights

MA Seyed, I Jantan, SNA Bukhari… - Journal of agricultural …, 2016 - ACS Publications
Cancer is a diverse class of diseases characterized by uncontrolled cell growth that
constitutes the greatest cause of mortality and morbidity worldwide. Despite steady progress …

Natural product triterpenoids and their semi-synthetic derivatives with potential anticancer activity

Y Ren, AD Kinghorn - Planta Medica, 2019 - thieme-connect.com
Triterpenoids are distributed widely in higher plants and are of interest because of their
structural diversity and broad range of bioactivities. In particular, there is a very large …

Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review

S Fakhri, SZ Moradi, MH Farzaei, A Bishayee - Seminars in cancer biology, 2022 - Elsevier
Several signaling pathways and basic metabolites are responsible for the control of
metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism …