Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

C Grander, F Grabherr, H Tilg - Cardiovascular Research, 2023 - academic.oup.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to
the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied …

Elevated liver biochemistries in hospitalized Chinese patients with severe COVID‐19: Systematic review and meta‐analysis

AJ Kovalic, G Huang, PJ Thuluvath, SK Satapathy - Hepatology, 2021 - journals.lww.com
Conclusions Comorbidities, including coronary artery disease, cerebrovascular disease and
chronic obstructive pulmonary disease, are more prevalent in hospitalized Chinese patients …

Silencing of FABP 1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease

T Mukai, M Egawa, T Takeuchi, H Yamashita… - FEBS open …, 2017 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence worldwide and has
been identified as a risk factor for cirrhosis and hepatocellular carcinoma. However, there is …

An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase

S Carotti, K Aquilano, F Valentini… - American Journal …, 2020 - journals.physiology.org
Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the
liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver …

Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis

F Wu, L Xu, Y Tu, OKW Cheung, LLM Szeto, MTS Mok… - Cancer letters, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is a major cancer burden worldwide with increasing
incidence in many developed countries. Super-enhancers (SEs) drive gene expressions …

[HTML][HTML] Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

Y Xia, E Andersson, SK Anand, E Cansby… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide
afflicting about one quarter of the adult population. NASH is a severe subtype of NAFLD …

Pathophysiological mechanisms and clinical associations of non-alcoholic fatty pancreas disease

A Pagkali, A Makris, K Brofidi, AP Agouridis… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Abstract Non-Alcoholic Fatty Pancreas disease (NAFPD), characterized by fat accumulation
in pancreatic tissue, is an emerging clinical entity. However, the clinical associations, the …

[HTML][HTML] Targeted delivery of Stk25 antisense oligonucleotides to hepatocytes protects mice against nonalcoholic fatty liver disease

E Cansby, E Nuñez-Durán, E Magnusson… - Cellular and Molecular …, 2019 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic
steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide …

The innovative medicines initiative− 10 years of public-private collaboration

H Laverty, P Meulien - Frontiers in medicine, 2019 - frontiersin.org
The Innovative Medicines Initiative (IMI) is a public-private partnership between the
European Union and the European pharmaceutical industry. Born of the necessity to foster …

Nobiletin alleviates non-alcoholic steatohepatitis in MCD-induced mice by regulating macrophage polarization

S Wang, T Lan, H Sheng, F Zheng, M Lei… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder that is characterized by
chronic activation of the hepatic inflammatory response and subsequent liver damage. The …