Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose

Y Zhu, J Zhang, W Zhang, W Mu - Biotechnology Advances, 2023 - Elsevier
Human milk oligosaccharides (HMOs), the third major solid component in breast milk, are
recognized as the first prebiotics for health benefits in infants. Sialylated HMOs are an …

Functional effects of human milk oligosaccharides (HMOs)

M Dinleyici, J Barbieur, EC Dinleyici, Y Vandenplas - Gut Microbes, 2023 - Taylor & Francis
Human milk oligosaccharides (HMOs) are the third most important solid component in
human milk and act in tandem with other bioactive components. Individual HMO levels and …

Biology of human milk oligosaccharides: From basic science to clinical evidence

N Sprenger, HLP Tytgat, A Binia… - Journal of Human …, 2022 - Wiley Online Library
Human milk oligosaccharides (HMOs) have been researched by scientists for over 100
years, driven by the substantial evidence for the nutritional and health benefits of mother's …

Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

C de Weerth, AK Aatsinki, MB Azad… - Critical reviews in …, 2023 - Taylor & Francis
Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond
documented positive effects of breastfeeding on infant and maternal health, there is …

Sialic acid, the secret gift for the brain

F Liu, AB Simpson, E D'Costa, FS Bunn… - Critical Reviews in …, 2023 - Taylor & Francis
The human brain grows rapidly in early life which requires adequate nutrition. Human milk
provides optimal nutrition for the developing brain, and breastfeeding significantly improves …

An extensively hydrolyzed formula supplemented with two human milk oligosaccharides modifies the fecal microbiome and metabolome in infants with cow's milk …

CL Boulangé, HK Pedersen, FP Martin… - International Journal of …, 2023 - mdpi.com
Cow's milk protein allergy (CMPA) is a prevalent food allergy among infants and young
children. We conducted a randomized, multicenter intervention study involving 194 non …

Effects of an extensively hydrolyzed formula supplemented with two human milk oligosaccharides on growth, tolerability, safety and infection risk in infants with cow's …

Y Vandenplas, M Żołnowska, R Berni Canani… - Nutrients, 2022 - mdpi.com
This randomized clinical trial (Registration: NCT03085134) assessed if an extensively
hydrolyzed formula (EHF) supplemented with two human milk oligosaccharides (HMO) and …

CRISPR-Cas-based identification of a sialylated human milk oligosaccharides utilization cluster in the infant gut commensal Bacteroides dorei

S Kijner, D Ennis, S Shmorak, A Florentin… - Nature …, 2024 - nature.com
The infant gut microbiome is impacted by early-life feeding, as human milk oligosaccharides
(HMOs) found in breastmilk cannot be digested by infants and serve as nutrients for their gut …

Infant formula with a specific blend of five human milk oligosaccharides drives the gut microbiota development and improves gut maturation markers: A randomized …

M Bosheva, I Tokodi, A Krasnow, HK Pedersen… - Frontiers in …, 2022 - frontiersin.org
Background Human milk oligosaccharides (HMOs) have important biological functions for a
healthy development in early life. Objective This study aimed to investigate gut maturation …