Inhibitors of histone deacetylases (HDACs) are nowadays part of the therapeutic arsenal
mainly against cancers, with four compounds approved by the Food and Drug …

Cathepsins are an important category of enzymes that have attracted great attention for the
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …

To enhance the accumulation and penetration of nanomedicines in tumor tissue, we
developed and evaluated the biological properties of matrix metalloproteinase 2 (MMP-2) …

More than 100 years ago, German physician Paul Ehrlich first proposed the concept of
selectively delivering “magic bullets” to tumors through targeting agents. The targeting …

Highly stable giant supramolecular vesicles were constructed by hierarchical self-assembly
of cucurbit [8] uril (CB [8])-based supra-amphiphiles for photoresponsive and targeted …

Prostate cancer is one of the most common non-cutaneous malignancies among men
worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or …

As a tumor-targeting and‑penetrating peptide, iRGD binds to αv integrins and neuropilin‑1
receptors, which are expressed at high levels on tumor cells and the surfaces of vasculature …

Peptide-drug conjugates (PDCs) are a class of novel molecules widely designed and
synthesized for delivering payload drugs. The peptide part plays a vital role in the whole …

Understanding that cancer is one of the most important health problems, especially in
advanced societies, is not difficult. The term of targeted cancer therapy has also been well …

Despite the well-documented therapeutic effects of histone deacetylase inhibitor (HDACi) on
various diseases, including arthritis and asthma, the therapeutic effect of HDACi on allergic …