Lignin, a major component of lignocellulose, is the largest source of aromatic building blocks
on the planet and harbors great potential to serve as starting material for the production of …

Employing phenols and phenol derivatives as electrophiles for cross-coupling reactions has
numerous advantages over commonly used aryl halides in terms of environmental …

Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in
both industry and academia. Even though cross-coupling reactions now represent mature …

Computational chemistry provides a versatile toolbox for studying mechanistic details of
catalytic reactions and holds promise to deliver practical strategies to enable the rational in …

Amides have been widely studied for decades, but their synthetic utility has remained limited
in reactions that proceed with rupture of the amide C–N bond. Using Ni catalysis, we have …

Metal-catalyzed cross-couplings represent one of the most important reaction platforms in
modern synthetic chemistry (Figure 1 A). 1 Although the field enjoys a rich history, there …

The distortion/interaction model has been used to explain and predict reactivity in a variety
of reactions where more common explanations, such as steric and electronic factors, do not …

Aryl halides are very useful electrophiles for synthesizing various substituted aromatic
compounds via metal-catalyzed cross-coupling reactions. Because of the high cost …

Herein, we developed an efficient and selective nickel-catalyzed monoalkylation of various
primary alcohols with aryl and heteroaryl amines together with diols and amino alcohol …

Amides are common functional groups that have been studied for more than a century. They
are the key building blocks of proteins and are present in a broad range of other natural and …