During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

Indirubin plays an important role in the treatment of many chronic diseases and exhibits
strong anti-inflammatory activity. However, the molecular mode of action during mastitis …

The development of topical formulations with advanced functions to overcome the poor and
sluggish permeability/bioavailability of traditional eye drops into interior of the eye is …

Inflammation is a natural host defensive process that is largely regulated by macrophages
during the innate immune response. Mitogen‐activated protein kinases (MAPKs) are proline …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

MAP Kinases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …

Recent studies show that AMPA receptor (-R) trafficking is important in synaptic plasticity.
However, the signaling controlling this trafficking is poorly understood. Small GTPases have …

In response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest
the cell cycle and initiate DNA repair. We show that, in the absence of p53, cells depend on …