ABSTRACT Objectives The World Health Organization estimated that a quarter of the global
population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis …

Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB)
infection. This term was used to define “a state of persistent immune response to stimulation …

Diagnosis of tuberculosis, and especially the diagnosis of extrapulmonary tuberculosis, still
faces challenges in clinical practice. There are several reasons for this. Methods based on …

BACKGROUND: Tuberculosis (TB) preventive therapy (TPT) decreases the risk of
developing TB disease and its associated morbidity and mortality. The aim of these clinical …

Background Multiple blood transcriptional signatures have been proposed for identification
of active and incipient tuberculosis. We aimed to compare the performance of systematically …

Background Use of an interferon-γ (IFN-γ) release assay or tuberculin skin test for detection
and management of latent tuberculosis infection is controversial. For both types of test, we …

Aim: Provide an overview of current available LTBI diagnostic test including updates, future
developments and perspectives. Results: There is currently no test for the direct …

Background Novel skin-based tests for tuberculosis infection might present suitable
alternatives to current tests; however, diagnostic performance of new tests compared with …

Tuberculosis (TB) remains an important problem among children in the United States and
throughout the world. There is no diagnostic reference standard for latent tuberculosis …

Background Evidence on the comparative performance of purified protein derivative
tuberculin skin tests (TST) and interferon-gamma release assays (IGRA) for predicting …