Pore-forming protein toxins (PFTs) are one of Nature's most potent biological weapons. An
essential feature of their toxicity is the remarkable property that PFTs can exist either in a …

332 PASTAN ET AL toxins kill many types of animal cells. Because of their potency, they
have been coupled to antibodies and growth factors in order to kill target cells with specific …

Before intoxication can occur, anthrax toxin protective antigen (PA), Pseudomonas exotoxin
A (PE), and diphtheria toxin (DT) must be activated by proteolytic cleavage at specific amino …

We have devised a strategy based on polymerase chain reaction (PCR) for the rapid cloning
of functional antibody genes as single-chain immunotoxins. RNA from a hybridoma …

Pseudomonas exotoxin (PE), a single-chain polypeptide toxin of 613 amino acids, consists
of three functional domains: an amino-terminal receptor-binding domain, a middle …

Pseudomonas exotoxin (PE) was incubated with cells and extracts analyzed for processed
fragments. PE was proteolytically cleaved to produce a N-terminal 28-kDa and a C-terminal …

Pseudomonas exotoxin (PE) is a 66,000 molecular weight protein secreted by
Pseudomonas aeruginosa. PE is made up of three domains, and PE40 is a form of PE which …

Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that
combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38 …

Pseudomonas exotoxin (PE) is a three-domain toxin which is cleaved by a cellular protease
within cells and then reduced to generate two prominent fragments (Ogata, M., Chaudhary …

The synthesis, standardization, and immunogenicity in young outbred mice and clinical
evaluation in adult volunteers of investigational vaccines designed to induce serum …