Aromatase inhibitors: A new approach for controlling ovarian function in cattle

MJ Yapura, EM Zwiefelhofer, RA Pierson, GP Adams - Theriogenology, 2018 - Elsevier
Numerous treatments and protocols have been used to control the reproductive cycle in
cattle, with varying effectiveness and many involving the administration of steroid hormones …

The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes

MB Kivrak, O Corum, H Alkan, O Atik, I Aydin, K Uney - Theriogenology, 2021 - Elsevier
The aim of this study was to determine the pharmacokinetics of letrozole and its effect on
FSH and LH concentrations after single (IV, IM, SC) and repeated IV doses in anestrous …

Research and development of a silicone letrozole-releasing device to control reproduction in cattle

EM Zwiefelhofer, BM Davis, GP Adams - Theriogenology, 2020 - Elsevier
Two experiments were conducted to test the effectiveness of a silicone matrix as an
intravaginal drug delivery device for letrozole, an aromatase inhibitor used for …

[HTML][HTML] Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs

L Lindh, H Lindeberg, A Banting, S Banting, S Sainmaa… - Theriogenology, 2020 - Elsevier
The interest in non-surgical approaches to contraception and fertility control in female dogs
has increased in recent years. In this study the effect of an aromatase inhibitor (finrozole) …

Synchronization of ovulation in cattle with an aromatase inhibitor–based protocol

MJ Yapura, RJ Mapletoft, RA Pierson, J Singh… - Theriogenology, 2016 - Elsevier
A study was designed to determine the effect of stage of the estrous cycle on the proportion
of animals that ovulated and the synchrony of ovulation of heifers treated with an aromatase …

Formulation and testing of a non-steroidal aromatase inhibitor intravaginal device for the control of ovarian function in cattle

J Yapura, I Badea, G Zamberlam, C Price… - Animal reproduction …, 2015 - Elsevier
The study was designed to formulate intravaginal devices that provide biologically active
circulating concentrations of an aromatase inhibitor for a minimum of 4 days, and to …

[PDF][PDF] A genetical genomics methodology to identify genetic markers of a bovine fertility phenotype based on CYP19A1 gene expression

N Guillemin, I Dufort, MA Sirard - Gene Expression to Genetical …, 2015 - researchgate.net
With the decrease in fertility in dairy cow, the interest towards means to control this variable
through genetic selection is growing. One of the most important factors controlling follicular …

The effects of preovulatory administration of oral letrozole on ovulatory follicle and the subsequent corpus luteum in mares

V Akbarinejad, F Gharagozlou… - Comparative Clinical …, 2017 - Springer
Progesterone acts as an important factor in maintenance of pregnancy and development of
equine embryo. Treatment with letrozole, a nonsteroidal inhibitor of aromatase enzyme …

Aromatase inhibitor-releasing intravaginal device

GP Adams, MJ Yapura, RA Pierson… - US Patent 10,004,723, 2018 - Google Patents
An intravaginal device that provides biologically active circulating concentrations of an
aromatase inhibitor for at least about of 4 days. Liposome-based and a wax-based …

[引用][C] A Genetical Genomics Methodology to Identify Genetic Markers of a Bovine Fertility Phenotype Based on CYP19A1 Gene Expression

PI Animales