The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

We describe here a new method for highly efficient detection of microRNAs by northern blot
analysis using LNA (locked nucleic acid)-modified oligonucleotides. In order to exploit the …

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA
nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar …

Abstract Background: MicroRNAs (miRNAs), small RNA molecules of approximately 22
nucleotides, have been shown to be up-or downregulated in specific cell types and disease …

In the last three decades, oligonucleotides have been extensively investigated as probes,
molecular ligands and even catalysts within therapeutic and diagnostic applications. The …

Locked nucleic acid (LNA) is a nucleic acid analogue that displays unprecedented
hybridization affinity towards complementary DNA and RNA. Structural studies have shown …

Compositions comprising first and second oligomers are pro vided wherein at least a portion
of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at …

Oligonucleotide chemistry has been developed greatly over the past three decades, with
many advances in increasing nuclease resistance, enhancing duplex stability and assisting …

Locked nucleic acids (LNA) show remarkable affinity and specificity against native DNA
targets. Effects of LNA modifications on mismatch discrimination were studied as a function …