Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It
affects nearly 95% of all protein-coding genes and occurs in nearly all human organs …

Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-
dependent degradation pathway that targets mRNAs with premature termination codons and …

Phospholipids represent a crucial component for the structure of cell membranes.
Phosphatidylcholine and phosphatidylethanolamine are two phospholipids that comprise …

Background The quality and quantity of tumor neoantigens derived from tumor mutations
determines the fate of the immune response in cancer. Frameshift mutations elicit better …

Disease represents a major problem in sustainable agricultural development. Plants interact
closely with various microorganisms during their development and in response to the …

Eukaryotic gene expression is regulated post-transcriptionally by a mechanism called
unproductive splicing, in which mRNA is triggered to degrade by the nonsense-mediated …

Exon junction complexes are deposited at exon-exon junctions during splicing. They are
primarily known to activate non-sense mediated degradation of transcripts harbouring …

During intravasation, cancer cells cross the endothelial barrier and enter the circulation.
Extracellular matrix stiffening has been correlated with tumor metastatic potential; however …

Nonsense-mediated mRNA decay (NMD) is an essential, highly conserved quality control
pathway that detects and degrades mRNAs containing premature termination codons …