Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Advances in epigenetics link genetics to the environment and disease

G Cavalli, E Heard - Nature, 2019 - nature.com
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice

Y Takahashi, MM Valencia, Y Yu, Y Ouchi, K Takahashi… - Cell, 2023 - cell.com
Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements

NM Shah, HJ Jang, Y Liang, JH Maeng, SC Tzeng… - Nature …, 2023 - nature.com
Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …

Trained immunity: adaptation within innate immune mechanisms

J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

Transposable elements in mammalian chromatin organization

HA Lawson, Y Liang, T Wang - Nature Reviews Genetics, 2023 - nature.com
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

Epigenetics in human obesity and type 2 diabetes

C Ling, T Rönn - Cell metabolism, 2019 - cell.com
Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Ten things you should know about transposable elements

G Bourque, KH Burns, M Gehring, V Gorbunova… - Genome biology, 2018 - Springer
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Measuring and interpreting transposable element expression

S Lanciano, G Cristofari - Nature Reviews Genetics, 2020 - nature.com
Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …