RNA-Seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types
The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …
strategies to understand and treat diseases. We characterized 29 immune cell types within …
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
R Roy Chowdhury, F Vallania, Q Yang… - Nature, 2018 - nature.com
Most infections with Mycobacterium tuberculosis (Mtb) manifest as a clinically asymptomatic,
contained state, known as latent tuberculosis infection, that affects approximately one …
contained state, known as latent tuberculosis infection, that affects approximately one …
Cellular senescence impairs the reversibility of pulmonary arterial hypertension
DE Van Der Feen, GPL Bossers… - Science Translational …, 2020 - science.org
Pulmonary arterial hypertension (PAH) in congenital cardiac shunts can be reversed by
hemodynamic unloading (HU) through shunt closure. However, this reversibility potential is …
hemodynamic unloading (HU) through shunt closure. However, this reversibility potential is …
Multi-domain adversarial learning
A Schoenauer-Sebag, L Heinrich… - arXiv preprint arXiv …, 2019 - arxiv.org
Multi-domain learning (MDL) aims at obtaining a model with minimal average risk across
multiple domains. Our empirical motivation is automated microscopy data, where cultured …
multiple domains. Our empirical motivation is automated microscopy data, where cultured …
KLRD1-expressing natural killer cells predict influenza susceptibility
Background Influenza infects tens of millions of people every year in the USA. Other than
notable risk groups, such as children and the elderly, it is difficult to predict what …
notable risk groups, such as children and the elderly, it is difficult to predict what …
[HTML][HTML] Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that follows an
unpredictable disease course and affects multiple organs and tissues. We performed an …
unpredictable disease course and affects multiple organs and tissues. We performed an …
Complementing single-cell RNA-seq using bulk transcriptional profiles
While high-throughput single cell technologies enable in depth examination of specific cell
subsets, these experiments lack the context of these subsets in other cell types and …
subsets, these experiments lack the context of these subsets in other cell types and …
[图书][B] Understanding Human Disease Through Integrated Molecular and Clinical Analyses
WA Haynes - 2018 - search.proquest.com
Traditional biomedical experiments are designed to study a single cohort for a single
disease using a single technology. I show that studying disease with a narrow lens has lead …
disease using a single technology. I show that studying disease with a narrow lens has lead …
Blood-based signatures for diagnosis and sub-typing of inflammatory bowel disease subsets
SJ Rubin, A Habtezion - US Patent App. 17/296,941, 2021 - Google Patents
This disclosure provides a method for analyzing peripheral blood leukocytes. In some
embodiments, method may com prise:(a) labeling peripheral blood leukocytes isolated from …
embodiments, method may com prise:(a) labeling peripheral blood leukocytes isolated from …
A Unified Molecular Signature of Systemic Lupus Erythematosus Revealed by Integrated, Multi-Cohort Transcriptomic Analysis
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that follows an
unpredictable disease course and affects multiple organs and tissues. We performed an …
unpredictable disease course and affects multiple organs and tissues. We performed an …