CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
Roles of IFN-γ in tumor progression and regression: a review
D Jorgovanovic, M Song, L Wang, Y Zhang - Biomarker research, 2020 - Springer
Background Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …
CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger - Nature Reviews Immunology, 2022 - nature.com
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity
M Boulch, M Cazaux, A Cuffel, MV Guerin, Z Garcia… - Nature Cancer, 2023 - nature.com
Abstract CD4+ T cells and CD4+ chimeric antigen receptor (CAR) T cells display highly
variable antitumor activity in preclinical models and in patients; however, the mechanisms …
variable antitumor activity in preclinical models and in patients; however, the mechanisms …
Milestones in tumor vascularization and its therapeutic targeting
M De Palma, D Hanahan - Nature cancer, 2024 - nature.com
Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …
launched more than 50 years ago with the proposition and experimental demonstrations that …
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
LB Ivashkiv - Nature Reviews Immunology, 2018 - nature.com
IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …
Interferon-gamma at the crossroads of tumor immune surveillance or evasion
F Castro, AP Cardoso, RM Gonçalves, K Serre… - Frontiers in …, 2018 - frontiersin.org
Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …
Endothelial activation and blood–brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells
Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen
receptor–modified T (CAR-T) cells can be complicated by neurologic adverse events (AE) in …
receptor–modified T (CAR-T) cells can be complicated by neurologic adverse events (AE) in …
Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment
M Yi, D Jiao, S Qin, Q Chu, K Wu, A Li - Molecular cancer, 2019 - Springer
Immune checkpoint inhibitor (ICI) activates host's anti-tumor immune response by blocking
negative regulatory immune signals. A series of clinical trials showed that ICI could …
negative regulatory immune signals. A series of clinical trials showed that ICI could …