International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

[HTML][HTML] Emerging roles of cystathionine β-synthase in various forms of cancer

K Ascenção, C Szabo - Redox biology, 2022 - Elsevier
The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Balneotherapy year in review 2021: focus on the mechanisms of action of balneotherapy in rheumatic diseases

S Cheleschi, S Tenti, I Seccafico, I Gálvez… - … Science and Pollution …, 2022 - Springer
Balneotherapy (BT) is one of the most commonly used non-pharmacologic complementary
therapies for different rheumatic diseases. Its beneficial properties probably derived from a …

Designing multifunctionalized selenium nanoparticles to reverse oxidative stress-induced spinal cord injury by attenuating ROS overproduction and mitochondria …

S Rao, Y Lin, Y Du, L He, G Huang, B Chen… - Journal of Materials …, 2019 - pubs.rsc.org
Spinal cord injury (SCI) remains a challenging clinical problem worldwide, due to the lack of
effective drugs for precise treatment. Among the complex pathophysiological events …

Protein S-sulfhydration: unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations

R Gupta, M Sahu, R Tripathi, RK Ambasta… - Ageing Research …, 2022 - Elsevier
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

The role of hydrogen sulfide on cardiovascular homeostasis: an overview with update on immunomodulation

LL Pan, M Qin, XH Liu, YZ Zhu - Frontiers in pharmacology, 2017 - frontiersin.org
Hydrogen sulfide (H2S), the third endogenous gaseous signaling molecule alongside nitric
oxide (NO) and carbon monoxide, is synthesized by multiple enzymes in cardiovascular …

PI3K/Akt and caspase pathways mediate oxidative stress-induced chondrocyte apoptosis

D Li, S Ni, KS Miao, C Zhuang - Cell Stress and Chaperones, 2019 - Springer
Chondrocyte apoptosis is closely related to the development and progression of
osteoarthritis (OA); however, the underlying mechanisms remain enigmatic. Previous studies …

Anti-cancerous potential of polysaccharide fractions extracted from peony seed dreg on various human cancer cell lines via cell cycle arrest and apoptosis

F Zhang, JJ Shi, K Thakur, F Hu, JG Zhang… - Frontiers in …, 2017 - frontiersin.org
In this study, four homo/heterogenous polysaccharides (HBSS, CHSS, DASS, and CASS)
extracted from peony seed dreg with respective molecular weights of 3467, 4677, 229, and …

Anti-osteoporosis effects of osteoking via reducing reactive oxygen species

D Qin, H Zhang, H Zhang, T Sun, H Zhao… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Osteoking is a Traditional Chinese Medicine consisting of
seven types of medicinal herbs originated from Yi nationality and has been used in clinic to …

Curculigoside protects against excess‐iron‐induced bone loss by attenuating Akt‐FoxO1‐dependent oxidative damage to mice and osteoblastic MC3T3‐E1 cells

Q Zhang, L Zhao, Y Shen, Y He… - Oxidative Medicine …, 2019 - Wiley Online Library
The present investigation found that curculigoside (CUR) can prevent excess‐iron‐induced
bone loss in mice and cells through antioxidation and inhibiting excess‐iron‐induced …