Atypical hemolytic–uremic syndrome
The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia,
thrombocytopenia, and renal impairment, occurs most frequently in young children. Most …
thrombocytopenia, and renal impairment, occurs most frequently in young children. Most …
Inherited kidney complement diseases
In the past 20 years, we have witnessed tremendous advances in our ability to diagnose and
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …
Zoonotic Enterohemorrhagic Escherichia coli: A One Health Perspective
A García, JG Fox, TE Besser - Ilar Journal, 2010 - academic.oup.com
Escherichia coli O157 and other enterohemorrhagic E. coli (EHEC) are food-and waterborne
zoonotic pathogens that cause diarrhea, hemorrhagic colitis, and hemolytic uremic …
zoonotic pathogens that cause diarrhea, hemorrhagic colitis, and hemolytic uremic …
Thrombotic microangiopathy: new insights
K Benz, K Amann - Current opinion in nephrology and …, 2010 - journals.lww.com
In HUS/TTP the kidney shows characteristic vascular changes due to endothelial damage,
that is, TMA, which should be clinically and morphologically differentiated from other …
that is, TMA, which should be clinically and morphologically differentiated from other …
Anti-factor B autoantibody in dense deposit disease
Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis
type II, is a rare kidney disorder that is associated with dysregulation of the alternative …
type II, is a rare kidney disorder that is associated with dysregulation of the alternative …
Shiga toxin pathogenesis: kidney complications and renal failure
TG Obrig, D Karpman - Ricin and Shiga Toxins: Pathogenesis, Immunity …, 2012 - Springer
The kidneys are the major organs affected in diarrhea-associated hemolytic uremic
syndrome (D+ HUS). The pathophysiology of renal disease in D+ HUS is largely the result of …
syndrome (D+ HUS). The pathophysiology of renal disease in D+ HUS is largely the result of …
Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura
P Jilma-Stohlawetz, ME Gorczyca… - Thrombosis and …, 2011 - thieme-connect.com
Thrombotic thrombocytopenic purpura (TTP) can cause severe organ damage due to
enhanced platelet aggregation by ultra-large von Wille-brand factor (VWF) multimers. Thus …
enhanced platelet aggregation by ultra-large von Wille-brand factor (VWF) multimers. Thus …
Heme drives susceptibility of glomerular endothelium to complement overactivation due to inefficient upregulation of heme oxygenase-1
O May, NS Merle, A Grunenwald, V Gnemmi… - Frontiers in …, 2018 - frontiersin.org
Atypical hemolytic uremic syndrome (aHUS) is a severe disease characterized by
microvascular endothelial cell (EC) lesions leading to thrombi formation, mechanical …
microvascular endothelial cell (EC) lesions leading to thrombi formation, mechanical …
Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
L Keir, RJM Coward - Pediatric nephrology, 2011 - Springer
Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic
syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the …
syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the …
Complement activation associated with ADAMTS13 deficiency in human and murine thrombotic microangiopathy
R Tati, AC Kristoffersson, A Ståhl, J Rebetz… - The Journal of …, 2013 - journals.aai.org
This study addressed the contribution of ADAMTS13 deficiency to complement activation in
thrombotic thrombocytopenic purpura (TTP). Renal tissue and blood samples were available …
thrombotic thrombocytopenic purpura (TTP). Renal tissue and blood samples were available …