Bone morphogenetic protein-2 in development and bone homeostasis

D Halloran, HW Durbano, A Nohe - Journal of developmental biology, 2020 - mdpi.com
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

Bone morphogenetic proteins

DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

EM Zeisberg, O Tarnavski, M Zeisberg, AL Dorfman… - Nature medicine, 2007 - nature.com
Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption
of normal myocardial structures, results from excessive deposition of extracellular matrix …

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH

RK Baboota, A Rawshani, L Bonnet, X Li, H Yang… - Nature …, 2022 - nature.com
The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and
non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed …

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

CE Murry, G Keller - Cell, 2008 - cell.com
The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

M Zeisberg, J Hanai, H Sugimoto, T Mammoto… - Nature medicine, 2003 - nature.com
Abstract Bone morphogenic protein (BMP)-7 is a 35-kDa homodimeric protein and a
member of the transforming growth factor (TGF)-β superfamily. BMP-7 expression is highest …

Stem cell niche: structure and function

L Li, T Xie - Annu. Rev. Cell Dev. Biol., 2005 - annualreviews.org
Adult tissue-specific stem cells have the capacity to self-renew and generate functional
differentiated cells that replenish lost cells throughout an organism's lifetime. Studies on …

[HTML][HTML] BMP signaling in mesenchymal stem cell differentiation and bone formation

M Beederman, JD Lamplot, G Nan, J Wang… - Journal of biomedical …, 2013 - ncbi.nlm.nih.gov
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and have
diverse functions during development and organogenesis. BMPs play a major role in …

Genetic analysis of the mammalian transforming growth factor-β superfamily

H Chang, CW Brown, MM Matzuk - Endocrine reviews, 2002 - academic.oup.com
Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors,
bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic …

Lung organogenesis

D Warburton, A El-Hashash, G Carraro, C Tiozzo… - Current topics in …, 2010 - Elsevier
Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …