Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

TH Bisgaard, KH Allin, L Keefer… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

CA Lamb, NA Kennedy, T Raine, PA Hendy, PJ Smith… - Gut, 2019 - gut.bmj.com
Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

The role of inflammation and the gut microbiome in depression and anxiety

JM Peirce, K Alviña - Journal of neuroscience research, 2019 - Wiley Online Library
The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

KM Fairbrass, SJ Costantino, DJ Gracie… - The lancet …, 2020 - thelancet.com
Background Patients with inflammatory bowel disease (IBD) often report symptoms
compatible with irritable bowel syndrome (IBS), which might have an effect on psychological …

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

LM Chen, CH Bao, Y Wu, SH Liang, D Wang… - Journal of …, 2021 - Springer
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's
disease (CD), is a group of chronic bowel diseases that are characterized by abdominal …

Bidirectional brain–gut axis effects influence mood and prognosis in IBD: a systematic review and meta-analysis

KM Fairbrass, J Lovatt, B Barberio, Y Yuan, DJ Gracie… - Gut, 2022 - gut.bmj.com
Objective The role of the brain–gut axis is of increasing interest in IBD, as the link between
common mental disorders and GI inflammation may be bidirectional. We performed a …

Bi-directionality of brain–gut interactions in patients with inflammatory bowel disease

DJ Gracie, EA Guthrie, PJ Hamlin, AC Ford - Gastroenterology, 2018 - Elsevier
Background & Aims Inflammatory bowel diseases (IBD) are associated with mood disorders,
such as anxiety or depression, but it is not clear whether one contributes to development of …

The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment

DJ Gracie, PJ Hamlin, AC Ford - The lancet Gastroenterology & …, 2019 - thelancet.com
Brain–gut interactions affect psychological wellbeing and symptom reporting in functional
gastrointestinal disorders; the presence of anxiety or depression is associated with the …

Evaluation of various estimators for standardized mean difference in meta‐analysis

L Lin, AM Aloe - Statistics in medicine, 2021 - Wiley Online Library
Meta‐analyses of a treatment's effect compared with a control frequently calculate the meta‐
effect from standardized mean differences (SMDs). SMDs are usually estimated by Cohen's …

Acceptance and commitment therapy reduces psychological stress in patients with inflammatory bowel diseases

B Wynne, L McHugh, W Gao, D Keegan, K Byrne… - Gastroenterology, 2019 - Elsevier
Background & Aims Patients with Crohn's disease or ulcerative colitis have relatively high
levels of stress and psychological dysfunction. Acceptance and commitment therapy (ACT) …