Bring the noise: reconceptualizing spontaneous neural activity

LQ Uddin - Trends in Cognitive Sciences, 2020 - cell.com
Definitions of what constitutes the 'signal of interest'in neuroscience can be controversial,
due in part to continuously evolving notions regarding the significance of spontaneous …

Neural mechanisms and psychology of psychedelic ego dissolution

D Stoliker, GF Egan, KJ Friston, A Razi - Pharmacological Reviews, 2022 - ASPET
Neuroimaging studies of psychedelics have advanced our understanding of hierarchical
brain organization and the mechanisms underlying their subjective and therapeutic effects …

[HTML][HTML] Geometric constraints on human brain function

JC Pang, KM Aquino, M Oldehinkel, PA Robinson… - Nature, 2023 - nature.com
The anatomy of the brain necessarily constrains its function, but precisely how remains
unclear. The classical and dominant paradigm in neuroscience is that neuronal dynamics …

The OpenNeuro resource for sharing of neuroscience data

CJ Markiewicz, KJ Gorgolewski, F Feingold, R Blair… - Elife, 2021 - elifesciences.org
The sharing of research data is essential to ensure reproducibility and maximize the impact
of public investments in scientific research. Here, we describe OpenNeuro, a BRAIN …

Characterization of regional differences in resting-state fMRI with a data-driven network model of brain dynamics

V Sip, M Hashemi, T Dickscheid, K Amunts… - Science …, 2023 - science.org
Model-based data analysis of whole-brain dynamics links the observed data to model
parameters in a network of neural masses. Recently, studies focused on the role of regional …

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

A Segal, L Parkes, K Aquino, SM Kia, T Wolfers… - Nature …, 2023 - nature.com
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …

[HTML][HTML] Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology

F Han, J Chen, A Belkin-Rosen, Y Gu, L Luo… - PLoS …, 2021 - journals.plos.org
The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau
proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance …

[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity

A Arnatkeviciute, BD Fulcher, MA Bellgrove, A Fornito - Neuroimage, 2021 - Elsevier
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …

[HTML][HTML] Imaging transcriptomics of brain disorders

A Arnatkeviciute, BD Fulcher, MA Bellgrove… - … Psychiatry Global Open …, 2022 - Elsevier
Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain
structure and function in vivo, and it has been used extensively to map the neural changes …

Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia

T Cramer, R Gill, ZS Thirouin, M Vaas, S Sampath… - Science …, 2022 - science.org
Microglia interact with neurons to facilitate synapse plasticity; however, signal (s)
contributing to microglia activation for synapse elimination in pathology are not fully …