Circuit changes in motor cortex during motor skill learning
Motor cortex is important for motor skill learning, particularly the dexterous skills necessary
for our favorite sports and careers. We are especially interested in understanding how …
for our favorite sports and careers. We are especially interested in understanding how …
The contribution of HCN channelopathies in different epileptic syndromes, mechanisms, modulators, and potential treatment targets: a systematic review
M Kessi, J Peng, H Duan, H He, B Chen… - Frontiers in Molecular …, 2022 - frontiersin.org
Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …
Spatially controlled, bipolar, cortical stimulation with high-capacitance, mechanically flexible subdural surface microelectrode arrays
I Uguz, KL Shepard - Science Advances, 2022 - science.org
Most neuromodulation approaches rely on extracellular electrical stimulation with
penetrating electrodes at the cost of cortical damage. Surface electrodes, in contrast, are …
penetrating electrodes at the cost of cortical damage. Surface electrodes, in contrast, are …
Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology
C Tocco, M Bertacchi, M Studer - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …
highly coordinated developmental events, such as cell proliferation, migration, and …
Perlecan domain-V enhances neurogenic brain repair after stroke in mice
AL Trout, MP Kahle, JM Roberts, A Marcelo… - Translational Stroke …, 2021 - Springer
The extracellular matrix fragment perlecan domain V is neuroprotective and functionally
restorative following experimental stroke. As neurogenesis is an important component of …
restorative following experimental stroke. As neurogenesis is an important component of …
[HTML][HTML] Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics
S Dura-Bernal, SA Neymotin, BA Suter, J Dacre… - Cell reports, 2023 - cell.com
Understanding cortical function requires studying multiple scales: molecular, cellular, circuit,
and behavioral. We develop a multiscale, biophysically detailed model of mouse primary …
and behavioral. We develop a multiscale, biophysically detailed model of mouse primary …
The structure of arm and hand movements in a spontaneous and food rewarded on-line string-pulling task by the mouse
Arm and hand use by the mouse have been studied in a variety of tasks in order to
understand the structure of skilled movements and motor learning, the anatomy and function …
understand the structure of skilled movements and motor learning, the anatomy and function …
COUP-TFI/Nr2f1 orchestrates intrinsic neuronal activity during development of the somatosensory cortex
The formation of functional cortical maps in the cerebral cortex results from a timely
regulated interaction between intrinsic genetic mechanisms and electrical activity. To …
regulated interaction between intrinsic genetic mechanisms and electrical activity. To …
Complex forelimb movements and cortical topography evoked by intracortical microstimulation in male and female mice
The motor cortex is crucial for the voluntary control of skilled movement in mammals and is
topographically organized into representations of the body (motor maps). Intracortical …
topographically organized into representations of the body (motor maps). Intracortical …