Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering
technology that endows the somatic cell genome with totipotency. Since the first report on …

Aberrant epigenetic reprogramming often results in developmental defects in somatic cell
nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight …

Assisted reproductive techniques developed for cattle in the last 25 years, like ovum pick up
(OPU), intracytoplasmic sperm injection (ICSI), and somatic cell nuclear transfer, have been …

Abstract The National Institutes of Health (NIH) miniature pig was developed specifically for
xenotransplantation and has been extensively used as a large-animal model in many other …

Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell
research and regenerative medicine for the past 20 years. The main biological goal of SCNT …

Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low
success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It …

Stem cells are characterized by their capability to self‐renew and terminally differentiate into
multiple cell types. Somatic or adult stem cells have a finite self‐renewal capacity and are …

Aberrant epigenetic reprogramming is a major factor of developmental failure of cloned
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …

The domestic goat (Capra aegagrus hircus), a mammalian species with high genetic merit
for production of milk and meat, can be a tremendously valuable tool for transgenic …