The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling
The activation of the TGF-beta pathway by activin A directs ES cells into the definitive
endoderm germ layer. However, there is evidence that activin A/TGF-beta is not solely …
endoderm germ layer. However, there is evidence that activin A/TGF-beta is not solely …
A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs
Germ layer formation is among the earliest differentiation events in metazoan embryos. In
triploblasts, three germ layers are formed, among which the endoderm gives rise to the …
triploblasts, three germ layers are formed, among which the endoderm gives rise to the …
Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension
K Wu, H Tang, R Lin, SG Carr, Z Wang… - Pulmonary …, 2020 - journals.sagepub.com
Platelet-derived growth factor is one of the major growth factors found in human and
mammalian serum and tissues. Abnormal activation of platelet-derived growth factor …
mammalian serum and tissues. Abnormal activation of platelet-derived growth factor …
Expression and function of PDGF-C in development and stem cells
Y Tian, Y Zhan, Q Jiang, W Lu, X Li - Open Biology, 2021 - royalsocietypublishing.org
Platelet-derived growth factor C (PDGF-C) is a relatively new member of the PDGF family,
discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and …
discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and …
PDGFD switches on stem cell endothelial commitment
The critical factors regulating stem cell endothelial commitment and renewal remain not well
understood. Here, using loss-and gain-of-function assays together with bioinformatic …
understood. Here, using loss-and gain-of-function assays together with bioinformatic …
From pluripotency to myogenesis: a multistep process in the dish
B Świerczek, MA Ciemerych, K Archacka - Journal of muscle research and …, 2015 - Springer
Pluripotent stem cells (PSCs), such as embryonic stem cells or induced pluripotent stem
cells are a promising source of cells for regenerative medicine as they can differentiate into …
cells are a promising source of cells for regenerative medicine as they can differentiate into …
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
LA Pereira, MS Wong, SM Lim, A Sides, EG Stanley… - PLoS …, 2011 - journals.plos.org
Mixl1 is a homeodomain transcription factor required for mesoderm and endoderm
patterning during mammalian embryogenesis. Despite its crucial function in development …
patterning during mammalian embryogenesis. Despite its crucial function in development …
A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy
A Raymond, B Liu, H Liang, C Wei, M Guindani… - …, 2014 - pmc.ncbi.nlm.nih.gov
Mesoderm Inducer in Xenopus Like1 (MIXL1), a paired-type homeobox transcription factor
induced by TGF-β family of ligands is required for early embryonic specification of …
induced by TGF-β family of ligands is required for early embryonic specification of …
[HTML][HTML] Mesenchymal Stem Cells Derived from Human Urine-Derived iPSCs Exhibit Low Immunogenicity and Reduced Immunomodulatory Profile
P Wang, Y Zhang, Z Li, S Zhou, Q Tang… - International Journal of …, 2024 - mdpi.com
Human-induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs)
represent a promising and renewable cell source for therapeutic applications. A systematic …
represent a promising and renewable cell source for therapeutic applications. A systematic …
The RUNX1+ 24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells
PI Ferrell, J Xi, C Ma, M Adlakha, DS Kaufman - Stem cells, 2015 - academic.oup.com
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a
key goal for the fields of developmental biology and regenerative medicine. Here, we use a …
key goal for the fields of developmental biology and regenerative medicine. Here, we use a …