DNA nanostructures interacting with lipid bilayer membranes

M Langecker, V Arnaut, J List… - Accounts of chemical …, 2014 - ACS Publications
Conspectus DNA has been previously shown to be useful as a material for the fabrication of
static nanoscale objects, and also for the realization of dynamic molecular devices and …

Nucleic acid amphiphiles: synthesis, properties, and applications

A Gubu, X Zhang, A Lu, B Zhang, Y Ma… - … Therapy-Nucleic Acids, 2023 - cell.com
Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups,
have been widely used in programmable bioengineering. Since nucleic acids are …

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

F Pi, DW Binzel, TJ Lee, Z Li, M Sun… - Nature …, 2018 - nature.com
Nanotechnology offers many benefits, and here we report an advantage of applying RNA
nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …

Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy

J Zhuang, J Tan, C Wu, J Zhang, T Liu… - Nucleic acids …, 2020 - academic.oup.com
Extracellular vesicles (EVs) hold great promise for transporting CRISPR–Cas9 RNA-guided
endonucleases (RNP) throughout the body. However, the cell-selective delivery of EVs is …

A quantitative assessment of the dynamic modification of lipid–DNA probes on live cell membranes

Y Bagheri, S Chedid, F Shafiei, B Zhao, M You - Chemical science, 2019 - pubs.rsc.org
Synthetic lipid–DNA probes have recently attracted much attention for cell membrane
analysis, transmembrane signal transduction, and regulating intercellular networks. These …

DNA nanostructures on membranes as tools for synthetic biology

A Czogalla, HG Franquelim, P Schwille - Biophysical journal, 2016 - cell.com
Over the last decade, functionally designed DNA nanostructures applied to lipid membranes
prompted important achievements in the fields of biophysics and synthetic biology. Taking …

Hybrid lipid oligonucleotide conjugates: synthesis, self-assemblies and biomedical applications

A Patwa, A Gissot, I Bestel, P Barthélémy - Chemical Society Reviews, 2011 - pubs.rsc.org
Hybrid lipid oligonucleotide conjugates: synthesis, self-assemblies and biomedical applications -
Chemical Society Reviews (RSC Publishing) DOI:10.1039/C1CS15038C Royal Society of …

Quantifying tensile forces at cell–cell junctions with a DNA-based fluorescent probe

B Zhao, N Li, T Xie, Y Bagheri, C Liang, P Keshri… - Chemical …, 2020 - pubs.rsc.org
Cells are physically contacting with each other. Direct and precise quantification of forces at
cell–cell junctions is still challenging. Herein, we have developed a DNA-based ratiometric …

Quantification of multivalent interactions by tracking single biological nanoparticle mobility on a lipid membrane

S Block, VP Zhdanov, F Hook - Nano letters, 2016 - ACS Publications
Macromolecular association commonly occurs via dynamic engagement of multiple weak
bonds referred to as multivalent interactions. The distribution of the number of bonds …

Switchable domain partitioning and diffusion of DNA origami rods on membranes

A Czogalla, EP Petrov, DJ Kauert, V Uzunova… - Faraday …, 2013 - pubs.rsc.org
Recently, DNA origami became a powerful tool for custom-shaped functional biomolecules.
In this paper, we present the first approach towards assembling amphipathic three …