The role of androgen and its related signals in PCOS

W Ye, T Xie, Y Song, L Zhou - Journal of cellular and molecular …, 2021 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at
reproductive age. However, the underlying pathogenic mechanisms have not been …

Obesity and androgens in women

R Pasquali, C Oriolo - Hyperandrogenism in Women, 2019 - karger.com
Androgen excess is often associated with obesity states, at any age of life, because of
changes in the pattern of secretion or metabolism of androgens and in their actions at the …

Androgen action in adipose tissue and the brain are key mediators in the development of PCOS traits in a mouse model

MJ Cox, MC Edwards, V Rodriguez Paris… - …, 2020 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a complex disorder characterized by endocrine,
reproductive, and metabolic abnormalities. Despite PCOS being the most common …

Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women

MM El-Eshmawy, A Ibrahim, R Bahriz… - BMC Endocrine …, 2022 - Springer
Background Features of metabolic syndrome such as abdominal obesity, insulin resistance,
hypertension and dyslipidemia are commonly encountered in polycystic ovary syndrome …

Revisiting the physiological role of androgens in women

E Rosato, F Sciarra, E Anastasiadou… - Expert Review of …, 2022 - Taylor & Francis
Introduction Extensive research underlines the critical functions of androgens in females.
Nevertheless, the precise mechanisms of their action are poorly understood. Here, we …

Mitochondria in sex hormone-induced disorder of energy metabolism in males and females

L Yin, M Luo, R Wang, J Ye, X Wang - Frontiers in Endocrinology, 2021 - frontiersin.org
Androgens have a complex role in the regulation of insulin sensitivity in the pathogenesis of
type 2 diabetes. In male subjects, a reduction in androgens increases the risk for insulin …

The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

VS Venkatesh, M Grossmann, JD Zajac… - Obesity …, 2022 - Wiley Online Library
Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males.
Here, we summarize recent evidence derived from clinical trials and studies in preclinical …

Current and emerging diagnostic and management approaches for idiopathic intracranial hypertension

R Piccus, M Thaller, AJ Sinclair… - Expert Review of …, 2023 - Taylor & Francis
Introduction Idiopathic intracranial hypertension is characterized by raised intracranial
pressure that triggers disabling headaches and can cause permanent visual loss. There is …

How to screen and prevent metabolic syndrome in patients of PCOS early: implications from metabolomics

X Zhao, X Feng, X Zhao, Y Jiang, X Li, J Niu… - Frontiers in …, 2021 - frontiersin.org
Background Polycystic ovary syndrome (PCOS) is a complex reproductive endocrine
disorder. And metabolic syndrome (MS) is an important bridge for PCOS patients to develop …

Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women

D Hang, X He, AS Kværner, AT Chan, K Wu, S Ogino… - BMC medicine, 2021 - Springer
Background Sex hormones have been suggested to play a role in colorectal cancer (CRC),
but their influence on early initiation of CRC remains unknown. Methods We retrospectively …