Background Liver transplantation is the only curative treatment option for end-stage liver
disease; however, its use remains limited due to a shortage of suitable organs. In recent …

In solid organ transplantation (Tx), both survival rates and quality of life have improved
dramatically over the last few decades. Each year, the number of people on the wait list …

Objective: Normothermic machine perfusion (NMP) enables optimized ex-vivo preservation
of a donor liver in a normal physiologic state. The impact of this emerging technology on …

Background Over 700 donor livers are discarded annually in the United States due to high
risk of poor graft function. The objective of this study was to determine the impact of using …

The ongoing organ shortage has forced transplant teams to develop alternate sources of
liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising …

Introduction Lung transplantation is an established treatment for patients with end-stage
lung disease. However, ischaemia reperfusion injury remains a barrier to achieving better …

Background. Ischemia-free liver transplantation (IFLT) has been innovated to avoid graft
ischemia during organ procurement, preservation, and implantation. However, the …

Transplant centers are currently facing a lack of tools to ensure adequate evaluation of the
quality of the available organs, as well as a significant shortage of kidney donors. Therefore …

Background Assessment of myocardial viability during ex situ heart perfusion (ESHP) is
based on the measurement of lactate concentrations. As this provides with limited …

Background There are still many offered donor livers that are declined during the allocation
process. Machine perfusion offers the option to evaluate (especially marginal) donor organs …