Machine learning meets omics: applications and perspectives
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …
characterization of the spatial organization and folding of the genome in the nucleus. In …
Genome-wide enhancer maps link risk variants to disease genes
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …
are associated with human diseases and complex traits, each of which could reveal insights …
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
Enhancer elements in the human genome control how genes are expressed in specific cell
types and harbor thousands of genetic variants that influence risk for common diseases …
types and harbor thousands of genetic variants that influence risk for common diseases …
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
V Steinthorsdottir, R McGinnis, NO Williams… - Nature …, 2020 - nature.com
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal
health. In genome-wide association meta-analysis of European and Central Asian mothers …
health. In genome-wide association meta-analysis of European and Central Asian mothers …
An atlas of dynamic chromatin landscapes in mouse fetal development
Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …
[HTML][HTML] A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Purpose Single cell (sc) analyses of key embryonic, fetal and adult stages were performed to
generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell …
generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell …
Generation and characterization of stable pig pregastrulation epiblast stem cell lines
Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad
prospects for human therapeutic model development and livestock breeding. Despite …
prospects for human therapeutic model development and livestock breeding. Despite …
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis
U Styrkarsdottir, SH Lund, G Thorleifsson, F Zink… - Nature …, 2018 - nature.com
Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …
SEdb: a comprehensive human super-enhancer database
Y Jiang, F Qian, X Bai, Y Liu, Q Wang, B Ai… - Nucleic acids …, 2019 - academic.oup.com
Super-enhancers are important for controlling and defining the expression of cell-specific
genes. With research on human disease and biological processes, human H3K27ac ChIP …
genes. With research on human disease and biological processes, human H3K27ac ChIP …