The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

This Review describes some of the approaches and techniques used today to derive in
silico models for the prediction of ADMET properties. The article also discusses some of the …

ADME prediction is an extremely challenging area as many of the properties we try to predict
are a result of multiple physiological processes. In this review we consider how in-silico …

Bioavailability of orally administered drugs can be influenced by a number of factors
including release from the formulation, dissolution, stability in the gastrointestinal (GI) …

A critically evaluated database of human intestinal absorption for 648 chemical compounds
is reported in this study, among which 579 are believed to be transported by passive …

Background Physiologically-based population pharmacokinetic modeling (popPBPK)
coupled with in vitro biopharmaceutics tools such as biorelevant dissolution testing can …

Variable selection is a procedure used to select the most important features to obtain as
much information as possible from a reduced amount of features. The selection stage is …

Motivation Accurate ADMET (an abbreviation for 'absorption, distribution, metabolism,
excretion and toxicity') predictions can efficiently screen out undesirable drug candidates in …

With the increase of complexity and risk in drug discovery processes, human intestinal
absorption (HIA) prediction has become more and more important. Up to now, some …

Absorption in the small intestine is one of the key processes determining the drug
bioavailability upon oral administration. Using fragmental descriptors and artificial neural …