Synthesis, characterization, and inhibition study of novel substituted phenylureido sulfaguanidine derivatives as α‐glycosidase and cholinesterase inhibitors
A series of six N‐carbamimidoyl‐4‐(3‐substituted phenylureido) benzenesulfonamide
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …
Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives
MAA Radwan, MA Alshubramy, M Abdel-Motaal… - Bioorganic …, 2020 - Elsevier
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …
Binding interactions of hydrophobically-modified flavonols with β-glucosidase: fluorescence spectroscopy and molecular modelling study
LV Chepeleva, OO Demidov, AD Snizhko… - RSC …, 2023 - pubs.rsc.org
Natural flavonoids are capable of inhibiting glucosidase activity, so they can be used for
treating diabetes mellitus and hypertension. However, molecular-level details of their …
treating diabetes mellitus and hypertension. However, molecular-level details of their …
Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: in vitro studies against yeast α …
This paper presents the efficient high yield synthesis of novel pyridine 2, 4, 6-
tricarbohydrazide derivatives (4a–4i) along with their α-glucosidase, acetylcholinesterase …
tricarbohydrazide derivatives (4a–4i) along with their α-glucosidase, acetylcholinesterase …
Organocatalyzed solvent free an efficient novel synthesis of 2, 4, 5-trisubstituted imidazoles for α-glucosidase inhibition to treat diabetes
A new and efficient solvent free synthesis of 2, 4, 5-trisubstituted imidazoles (3a–3j) was
achieved by N-acetyl glycine (NAG) catalyzed three components condensation of …
achieved by N-acetyl glycine (NAG) catalyzed three components condensation of …
Synthesis of Novel Derivatives of 5, 6, 7, 8-Tetrahydroquinazolines Using α-Aminoamidines and In Silico Screening of Their Biological Activity
AD Snizhko, AV Kyrychenko, ES Gladkov - International Journal of …, 2022 - mdpi.com
α-Aminoamidines are promising reagents for the synthesis of a diverse family of pyrimidine
ring derivatives. Here, we demonstrate the use of α-aminoamidines for the synthesis of a …
ring derivatives. Here, we demonstrate the use of α-aminoamidines for the synthesis of a …
Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1, 3, 4-oxadiazole-2-thione derivatives
Thymidine phosphorylase (TP) inhibitors have attracted great attention due to their ability to
suppress the tumors formation. In our ongoing research, a series of 1, 3, 4-oxadiazole-2 …
suppress the tumors formation. In our ongoing research, a series of 1, 3, 4-oxadiazole-2 …
Novel substituted 3-phenyl 1-(4-(5-bromopyridin-3-yl)-6-phenylpyrimidin-2-yl)-thiourea compounds as key small organic molecules for the potential treatment of type II …
T Ur Rehman, I Ullah Khan, S Riaz - Medicinal Chemistry Research, 2017 - Springer
In this paper, we report a series of eighteen novel pyrimidine-based thiourea compounds
with good to excellent yields (61–88%). The chemical structures of these heterocycles …
with good to excellent yields (61–88%). The chemical structures of these heterocycles …
Synthesis, density functional theory calculations and luminescence of lanthanide complexes with 2, 6‐bis [(3‐methoxybenzylidene) hydrazinocarbonyl] pyridine Schiff …
A pyridine‐diacylhydrazone Schiff base ligand, L= 2, 6‐bis [(3‐methoxy benzylidene)
hydrazinocarbonyl] pyridine was prepared and characterized by single crystal X‐ray …
hydrazinocarbonyl] pyridine was prepared and characterized by single crystal X‐ray …
[HTML][HTML] A novel synthetic ursolic acid derivative inhibits growth and induces apoptosis in breast cancer cell lines
W Li, H Zhang, M Nie, W Wang, Z Liu… - Oncology …, 2018 - spandidos-publications.com
The present study investigated the anticancer functions of ursolic acid (UA) and its novel
derivatives, with a nitrogen‑containing heterocyclic scaffold and the privileged fragment at …
derivatives, with a nitrogen‑containing heterocyclic scaffold and the privileged fragment at …