Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule
identified. ACh signalling in the neuronal cholinergic system has long been known to …

Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral
disorder with a high regional incidence and malignant rate. With the development of the …

Betel quid (BQ) is a package of mixed constituents that is chewed by more than 600 million
people worldwide, particularly in Asia. The formulation of BQ depends on a variety of factors …

Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival
rate of around 50% after treatment. Epigenetic modifications are considered to have a key …

New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We
conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived …

New psychoactive substances (NPS) can be divided into two main groups: synthetic
molecules and active principles of natural origin. With respect to this latter group, a wide …

Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal
fibrosis and oral squamous cell carcinoma (OSCC), however the mechanism remains …

Areca nut and slaked lime, with or without tobacco wrapped in Piper betle leaf, prepared as
betel quid, is extensively consumed as a masticatory product in many countries across the …

Simple Summary Head and neck squamous cell carcinoma (HNSCC) encompasses a
variety of tumors developing in the head and neck region, mainly affecting the oral cavity …

Background DNA hypermethylation of tumor suppressor genes is observed in precancerous
lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has …