Applications of asymmetric organocatalysis in medicinal chemistry

J Alemán, S Cabrera - Chemical Society Reviews, 2013 - pubs.rsc.org
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts,
has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched …

Bifunctional primary amine-thioureas in asymmetric organocatalysis

OV Serdyuk, CM Heckel, SB Tsogoeva - Organic & biomolecular …, 2013 - pubs.rsc.org
Research disclosed since the demonstration of the first examples of primary amine-thiourea
organocatalysis in 2006 has shown that primary amine-based thioureas can successfully …

Recent developments in next generation (S)-proline-derived chiral organocatalysts

E Juaristi - Tetrahedron, 2021 - Elsevier
In the area of asymmetric organocatalysis, significant effort has been dedicated during the
last decade to improve the performance of emblematic catalysts such as proline, as well as …

Enantioselective organocatalyzed transformations of β-ketoesters

T Govender, PI Arvidsson, GEM Maguire… - Chemical …, 2016 - ACS Publications
The β-ketoester structural motif continues to intrigue chemists with its electrophilic and
nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and …

Chiral Squaramide‐Catalyzed Highly Enantioselective Michael Addition of 2‐Hydroxy‐1, 4‐naphthoquinones to Nitroalkenes

W Yang, DM Du - Advanced Synthesis & Catalysis, 2011 - Wiley Online Library
A chiral squaramide‐organocatalyzed, highly enantioselective Michael addition of 2‐
hydroxy‐1, 4‐naphthoquinones to nitroalkenes has been developed. This reaction afforded …

One-pot synthesis of ureas from Boc-protected amines

C Spyropoulos, CG Kokotos - The Journal of organic chemistry, 2014 - ACS Publications
A practical one-pot synthesis of ureas is described. Boc-protected amines can be
transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas …

Chiral bifunctional thiourea-catalyzed enantioselective Michael addition of ketones to nitrodienes

H Ma, K Liu, FG Zhang, CL Zhu, J Nie… - The Journal of Organic …, 2010 - ACS Publications
Simple bifunctional thioureas, derived from the commercially available saccharides and
chiral diamines, have been shown tunably to promote Michael-type addition of ketones to α …

An asymmetric Michael addition of α, α-disubstituted aldehydes to maleimides leading to a one-pot enantioselective synthesis of lactones catalyzed by amino acids

CG Kokotos - Organic Letters, 2013 - ACS Publications
A cheap and fast construction of both enantiomers of substituted succinimides is reported. α-
or β-amino acids, such as β-phenylalanine and α-tert-butyl aspartate, were found to be …

Construction of tertiary alcohols bearing perfluoroalkyl chains catalyzed by prolinamide-thioureas

CG Kokotos - The Journal of Organic Chemistry, 2012 - ACS Publications
A systematic study to evaluate the ability of various organocatalysts to catalyze the aldol
reaction between acetone and 2, 2, 2-trifluoromethyl-1-phenylethanone was undertaken …

Terpene‐Derived Bifunctional Thioureas in Asymmetric Organocatalysis

S Narayanaperumal, DG Rivera, RC Silva… - …, 2013 - Wiley Online Library
Chiral hydrogen‐bond donors have played a crucial role in the progress of asymmetric
catalysis as an essential tool in modern organic synthesis. Among these donors, thioureas …