The biology and rationale of targeting nectin-4 in urothelial carcinoma

EI Heath, JE Rosenberg - Nature Reviews Urology, 2021 - nature.com
Bladder cancer is the tenth most common cancer type worldwide. Urothelial carcinoma is the
most common type of bladder cancer and accounts for 90% of bladder cancer cases in the …

Prognostic and prediction tools in bladder cancer: a comprehensive review of the literature

LA Kluth, PC Black, BH Bochner, J Catto, SP Lerner… - European urology, 2015 - Elsevier
Context This review focuses on risk assessment and prediction tools for bladder cancer
(BCa). Objective To review the current knowledge on risk assessment and prediction tools to …

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Z Chen, L Zhou, L Liu, Y Hou, M Xiong, Y Yang… - Nature …, 2020 - nature.com
Although substantial progress has been made in cancer biology and treatment, clinical
outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor …

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

JS Damrauer, KA Hoadley, DD Chism… - Proceedings of the …, 2014 - National Acad Sciences
We sought to define whether there are intrinsic molecular subtypes of high-grade bladder
cancer. Consensus clustering performed on gene expression data from a meta-dataset of …

Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy

MM Tu, HA Abdel-Hafiz, RT Jones, A Jean… - Communications …, 2020 - nature.com
Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical
management of multiple cancer types, however, many tumors still fail to respond. CCL2 is …

Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer

M Zhou, Z Zhang, S Bao, P Hou, C Yan… - Briefings in …, 2021 - academic.oup.com
Long noncoding RNAs (lncRNAs) have been associated with cancer immunity regulation
and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating …

EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype

S Rebouissou, I Bernard-Pierrot… - Science translational …, 2014 - science.org
Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …

Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for muscle-invasive urothelial cancer

G Chu, X Ji, Y Wang, H Niu - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Muscle-invasive urothelial cancer (MUC), characterized by high aggressiveness and
significant heterogeneity, is currently lacking highly precise individualized treatment options …

Modelling bladder cancer in mice: opportunities and challenges

T Kobayashi, TB Owczarek, JM McKiernan… - Nature reviews …, 2015 - nature.com
The prognosis and treatment of bladder cancer have improved little in the past 20 years.
Bladder cancer remains a debilitating and often fatal disease, and is among the most costly …

[HTML][HTML] Systemic immune-inflammation index predicts prognosis of bladder cancer patients after radical cystectomy

W Zhang, R Wang, W Ma, Y Wu, N Maskey… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background The systemic immune-inflammation index (SII) has been used as a prognostic
marker for several cancer types, but there is no in-depth study in bladder cancer. This study …