Engineering and design of chimeric antigen receptors
T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new
class of therapeutics for cancer, based on their remarkable potency in blood cancers. Since …
class of therapeutics for cancer, based on their remarkable potency in blood cancers. Since …
Animal models of human disease: zebrafish swim into view
GJ Lieschke, PD Currie - Nature Reviews Genetics, 2007 - nature.com
Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs
KM Kwan, E Fujimoto, C Grabher… - … dynamics: an official …, 2007 - Wiley Online Library
Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has
suffered from three problems: the labor of building complex expression constructs using …
suffered from three problems: the labor of building complex expression constructs using …
An optogenetic gene expression system with rapid activation and deactivation kinetics
LB Motta-Mena, A Reade, MJ Mallory, S Glantz… - Nature chemical …, 2014 - nature.com
Optogenetic gene expression systems can control transcription with spatial and temporal
detail unequaled with traditional inducible promoter systems. However, current eukaryotic …
detail unequaled with traditional inducible promoter systems. However, current eukaryotic …
DNA transposons: nature and applications in genomics
M Muñoz-López, JL García-Pérez - Current genomics, 2010 - ingentaconnect.com
Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …
repetitive elements are able to move within the genome (transposons and retrotransposons) …
Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty, piggyBac and Tol2 for Genome Engineering
N Sandoval-Villegas, W Nurieva, M Amberger… - International journal of …, 2021 - mdpi.com
Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …
Interception of host angiogenic signalling limits mycobacterial growth
Pathogenic mycobacteria induce the formation of complex cellular aggregates called
granulomas that are the hallmark of tuberculosis,. Here we examine the development and …
granulomas that are the hallmark of tuberculosis,. Here we examine the development and …
Tol2: a versatile gene transfer vector in vertebrates
K Kawakami - Genome biology, 2007 - Springer
The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …
transposase. The transposase protein can catalyze transposition of a transposon construct …
Adult neurogenesis and brain regeneration in zebrafish
Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …
and the underlying activity of the adult neural stem cells differ vastly among species. In …
An ancestral mycobacterial effector promotes dissemination of infection
JW Saelens, MI Sweeney, G Viswanathan, AM Xet-Mull… - Cell, 2022 - cell.com
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …