Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Liver fibrosis refers to the process underlying the development of chronic liver diseases,
wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive …

Background and Aims In clinical and experimental NASH, the origin of the scar‐forming
myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail …

Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic
cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis …

The liver can succumb to oxidant damage during the development of chronic liver diseases.
Despite their physiological relevance to hepatic homeostasis, excessive reactive …