Metabolomics in infectious diseases and drug discovery
Metabolomics has emerged as an invaluable tool that can be used along with genomics,
transcriptomics and proteomics to understand host–pathogen interactions at small-molecule …
transcriptomics and proteomics to understand host–pathogen interactions at small-molecule …
The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …
Incomplete systemic recovery and metabolic phenoreversion in post-acute-phase nonhospitalized COVID-19 patients: implications for assessment of post-acute …
We present a multivariate metabotyping approach to assess the functional recovery of
nonhospitalized COVID-19 patients and the possible biochemical sequelae of “Post-Acute …
nonhospitalized COVID-19 patients and the possible biochemical sequelae of “Post-Acute …
Systemic perturbations in amine and kynurenine metabolism associated with acute SARS-CoV-2 infection and inflammatory cytokine responses
We performed quantitative metabolic phenotyping of blood plasma in parallel with
cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+)(n= 10) or …
cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+)(n= 10) or …
Metabolomic analyses reveal new stage-specific features of COVID-19
H Jia, C Liu, D Li, Q Huang, D Liu… - European …, 2022 - Eur Respiratory Soc
The current pandemic of coronavirus disease 2019 (COVID-19) has affected> 160 million
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …
Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity
There is an urgent need to identify which COVID-19 patients will develop life-threatening
illness so that medical resources can be optimally allocated and rapid treatment can be …
illness so that medical resources can be optimally allocated and rapid treatment can be …
Altered high-density lipoprotein composition and functions during severe COVID-19
F Begue, S Tanaka, Z Mouktadi, P Rondeau… - Scientific reports, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) pandemic is affecting millions of patients
worldwide. The consequences of initial exposure to SARS-CoV-2 go beyond pulmonary …
worldwide. The consequences of initial exposure to SARS-CoV-2 go beyond pulmonary …
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome
Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of
viral nucleic acid sequences. Properties of the host response are not measured but are key …
viral nucleic acid sequences. Properties of the host response are not measured but are key …
Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a
relevant threat to global health. SARS-CoV-2 infection is characterized by a wide range of …
relevant threat to global health. SARS-CoV-2 infection is characterized by a wide range of …
Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19
T Matsuyama, SK Yoshinaga, K Shibue… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …
develop our understanding of the nature of the disease and its effects on human immunity …