Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Iron deficiency is a common condition increasingly diagnosed and treated by
gastroenterologists. The most common presentation of iron deficiency is anaemia; however …

Iron-sulfur (Fe/S) proteins are involved in a wide variety of cellular processes such as
enzymatic reactions, respiration, cofactor biosynthesis, ribosome biogenesis, regulation of …

Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the
nuclear genome, are involved in multiple human diseases. Here, we report that in …

Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid
hormones in adrenal glands. As a member of the [2Fe-2S] cluster-containing ferredoxin …

Glutathione contributes to thiol‐redox control and to extra‐mitochondrial iron–sulphur cluster
(ISC) maturation. To determine the physiological importance of these functions and sort out …

Iron is an essential nutrient for cells. It is unknown how iron, after its import into the cytosol, is
specifically delivered to iron-dependent processes in various cellular compartments. Here …

Mitochondria are important integrators of cellular function and therefore affect the
homeostatic balance of the cell. Besides their important role in producing adenosine …

BACKGROUND: Iron is an essential element for life, as it is a cofactor for enzymes involved
in many metabolic processes, but it can also be harmful, since its excess is thought to …